Hundreds of bikers are expected to bring traffic to a standstill in a mass protest at the record price of petrol.
Demonstrators claim the May 1st "May-Hem" protest on roads and motorways around Manchester will be the biggest ever held, and although police say there has been no indication of how many bikers will take part they warn there could be "significant delays" to other motorists.
Past protests in the last two years have seen hundreds of bikers take over sections of motorways, travelling en mass at 25mph.
Organisers on biker websites say with a looming General Election it is a chance to show the "political elite" they want fuel duty cut.
The AA's monthly fuel price report for April says petrol prices have reached a new record high, having broken the previous record of 119.7p a litre set in July 2008.
Rising wholesale costs, a 1p increase in fuel duty on April 1st and a higher price for oil continue to push pump prices up by one to two-tenths of a penny a day, the organisation said, with the UK having the eleventh highest unleaded price in Europe and the second highest diesel price.
Greater Manchester Police have said they are working to minimise any disruption to other drivers and businesses during the protest.
Bikers will gather at the westbound Hartshead Moor Services on the M62 in West Yorkshire before heading for Manchester on the M62, onto the M60 and then from M60 Junction 12 onto the M602 towards Manchester. Some demonstrators are then expected to leave the M602 at the roundabout with the A57 Regent Road and use the A5063 Trafford Road into Salford Quays.
The remaining demonstrators, controlled by a police convoy, will join Albion Way from the M602 roundabout and head into Manchester city centre.
Police advise road users planning to travel along the route to check traffic conditions before setting out by checking the Highways Agency website at www.highways.gov.uk/traffic.