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Commonly used drug 'can help heart attack victims'

By Tom White

A drug commonly used after transplant surgery could hold the key to limiting the damage suffered following a heart attack, new research has claimed.

The study concluded that temporarily decreasing a part of someone's immune system could be beneficial to them immediately after a heart attack.

Drugs like cyclosporin are used to do exactly that after a transplant, to stop the body rejecting a donated organ, and scientists believe they have found another use for it.

During a heart attack, a clot starves the heart of blood and can cause lasting damage. The heart is then damaged further by a mixture of chemicals and cells that rush in to the heart as blood flow is restored.

Currently doctors are unable to prevent or repair this damage and do not fully understand how the chemical build-up causes such severe damage.

The findings suggest that white blood cells are responsible for much of the damage, as they can become activated during a heart attack and travel in to the heart muscle.

Once inside the muscle tissue, they can release toxic chemicals that kill off parts of the heart. Normally these cells and their toxic chemicals would be used to fight infection.

Professor Ioakim Spyridopoulos, director of the Newcastle University Cardiovascular Research Centre, said: "The beauty of this research is that we have used our new understanding of what happens inside the heart to help identify a potential drug that is already in use. If successful, heart attack patients could see the benefit of the study within a few years."

Belfast Telegraph


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