Erne Integrated College in Enniskillen is preparing to welcome back 365 pupils and 75 staff from early next week and principal Jimmy Jackson-Ware admits to feeling "apprehensive".
"It's concerning and while we're following the Education Minister's guidance as best we can, it's unknown territory," he said.
"Our view is that we're going to have to feel our way through this and accept that we may have to review things week by week and revise as we learn.
"The staff are very worried, some more than others and understandably so, and they will need reassurance.
"In my view it's all been very last-minute with insufficient guidance and support and too much has been left to the interpretation of principals themselves."
Mr Jackson-Ware says receiving a 70-page document on August 13 - the same day as the A-level results were published - has been "chaotic".
"I'm in two minds about the whole thing. While it's the right decision for children to be back at school in terms of their mental wellbeing and to provide structure, the horse has bolted and we've missed the opportunity to prepare in advance.
"Now we just have to get on with it but we knew this was coming and it should have been planned for a long time ago.
"For both our staff and students it's going to be about taking personal responsibility to make this work."
Mr Jackson-Ware says staggered starts to avoid mixing was not an option for his rural school which depends on transport for students, some of whom live 26 miles away in Belleek, close to the Co Donegal border.
"We have decided that for key stage Years 8 to 10, students stay in their form classes or bubbles all day long, similar to a primary set-up and the teachers will go to them," he explained.
"That's going to be a challenge for students who will get restless staying in the same room all day long, but we'll have comfort breaks at staggered intervals with social distancing.
"For all other years it just wouldn't work with the range of different GCSE subjects and large class numbers in core subjects. So we'll just have to minimise the interactions with staggered break and lunch times.
"That's the best we can do."