A new £13 million adult hospice will be completed this spring.
It will include 18 beds in single en-suite rooms with supporting facilities for staff, families and volunteers. A new day hospice facility and a dedicated education and resource centre are planned.
The Northern Ireland Hospice cares for more than 3,000 adults each year and is preparing to help more people at its new centre in North Belfast.
Heather Weir, Northern Ireland Hospice chief executive, said: "We could never have reached this stage of building the new hospice without the financial support from fundraisers.
"I would like to pay tribute to all of our donors that have supported so far. Individuals and groups in the community, charitable trusts, corporate sponsors and government support have all been instrumental in getting us this far."
The first and deputy first ministers and health minister visited the construction site on Thursday.
The building was partly funded by the Department of Health, Social Services and Public Safety (DHSSPS) through a £2.7 million grant.
First Minister Arlene Foster said: "The organisation's vision of access for all to world class palliative care is coming to reality here today thanks to the dedicated work of the Northern Ireland Hospice.
"I commend the hospice in its work to reach out beyond cancer to help those people most in need of the selfless commitment and care provided here."
Deputy First Minister Martin McGuinness said it was the first purpose-built and dementia-friendly hospice anywhere in the UK and Ireland.
"This visionary project will support our future generations and I am both humbled and inspired to see such progress and determination by all the people engaged with the hospice."