The Republic of Ireland's Justice Minister Dermot Ahern will meet with his counterparts from Scotland and Northern Ireland to discuss security and crime in the three jurisdictions.
Human trafficking, organised crime gangs and approaches on how to reduce reoffending will also top the agenda at the summit close to the border in Dundalk, Co Louth.
Mr Ahern is hosting the first trilateral meeting with Scottish cabinet secretary for justice, Kenny MacAskill, and the Northern minister for policing and criminal justice, David Ford.
A spokesman for Mr Ahern said the ministers will discuss criminal justice matters, taking account of the similar issues facing each of their jurisdictions and the need for the closest possible co-operation between them.
"The meeting will focus primarily on issues of common interest relating to human trafficking, organised crime, forensic science, DNA databases, police training and approaches to reducing offending," he said.
"The ministers will review measures being taken in each jurisdiction to deal with human trafficking and the co-operation of the law enforcement authorities in coping with an evil which respects no borders."
Elsewhere Mr Ahern will brief colleagues on developments in the Republic in relation to organised crime.
The meeting comes just days after UK Home Secretary Theresa May warned dissident republicans could attempt to mount a new wave of terrorist attacks on the British mainland.