Belfast's Days Hotel, in Hope Street, is to undergo a £2.5 million upgrade.
The hotel is being rebranded as Holiday Inn Belfast City Centre later this summer.
The building is owned and operated by Andras Hotels, which also owns the Holiday Inn hotel near Queen's University.
The parent company of the Holiday Inn brand, InterContinental Hotels Group (IHG), has awarded the franchise to Andras.
Andras Hotels director Rajesh Rana said: "We are investing heavily in this city centre property to bring it up to the high standards our guests expect from a Holiday Inn hotel, and the £2.5 million investment will see the property utterly transformed.
"At 250 bedrooms, the quality and size of this Holiday Inn hotel, along with its international recognition, will be a great benefit to Visit Belfast when selling Belfast as a conference venue."
Anna Corkill, development director for the UK and Ireland at IHG, said: "Belfast is a fantastic city and we are delighted to be developing this property with Andras Hotels who are a long-standing partner of ours. Holiday Inn Belfast City Centre will be a great addition to our portfolio and we look forward to its opening."
The first phase of the refit will be completed in mid-August with the work due to be finished next year.