Lough Erne Resort has been evacuating following a fire in the main building on Friday evening.
Police and emergency services are currently dealing with the incident.
No one is said to have been injured.
A spokesperson from the Enniskillen hotel said "a fire had broken out adjacent to the hotel's reception area."
They said: "In line with our normal emergency planning all guests were evacuated to a separate area within the hotel. The Fire Service was contacted immediately and arrived quickly to deal with the incident.
"Guests are advised to check with the hotel prior to arrival on Saturday and Sunday."
A full enquiry to establish the cause of the incident in underway.