Theresa May has told how not having children has been "very sad", but said her Christian faith had helped her to cope.
In a rare glimpse into her personal life, the Prime Minister said that instead of losing her faith, it helped her to deal with the tragedies.
She told LBC: "It's been very sad, it just turned out not to be possible. We are not the only couple that finds ourselves in that situation, and when you do I suppose you just get on with life"
Mrs May was 25 when her father, Rev Hugh Brasier, was killed in a car crash, and her mother, Zaidee, died a few months later.
"It did have quite an impact on me," Mrs May said. "I was very fortunate in that I had been married not that long beforehand and Philip has been a fantastic support for me. He really was my rock at that time.
"I was an only child, so I didn't have brothers and sisters that I could share it with. Suddenly, there I was without the two people who had brought me up and had meant so much to me.
"It did have an impact and I think part of that impact was about reinforcing the belief in and importance of public service that I'd learned from my parents. I think my faith helped in just being a support there for me."