Belfast Telegraph

Northern Ireland scientist gets £855k for her cancer research

Dr Helen Coleman, who has received a grant of over £855,000 for cancer research, wears a unity band to support World Cancer Day
Dr Helen Coleman, who has received a grant of over £855,000 for cancer research, wears a unity band to support World Cancer Day

By Gillian Halliday

A leading Queen's University scientist has been awarded more than £855,000 by Cancer Research UK to find new ways to prevent oesophageal cancer and improve survival rates.

Dr Helen Coleman (34), from Portaferry, was granted the prestigious Cancer Research UK Career Establishment Award ahead of World Cancer Day today.

She said she was inspired to work in cancer research after several family members - including her husband Eamonn's uncle, Sean Lennon - were diagnosed with the disease.

Dr Coleman said: "Both my parents received cancer diagnoses but thankfully survived.

"I also know about the devastating impact of oesophageal cancer after three members of my husband's family were diagnosed with the disease.

"One uncle is a survivor, after he was diagnosed early enough to be treated with surgery - but the family sadly lost his other uncle and our sister-in-law's father to the disease, both within two years of their diagnosis.

"Every hour someone in Northern Ireland is diagnosed with cancer and I feel it's really important to support life-saving cancer research.

"One way to do so is by wearing a unity band to mark World Cancer Day.

"Every band worn and every pound donated will help us beat cancer sooner."

Over the next six years, Dr Coleman will analyse data from around 20,000 patients with Barrett's oesophagus [a risk factor in developing oesophageal cancer], and over 3,000 oesophageal cancer patients.

More than 200 people are diagnosed with oesophageal cancer in Northern Ireland every year and fewer than one in five will survive for at least five years after diagnosis.

Barrett's oesophagus, a condition where some of the cells lining the food pipe have started to change, is much more common, with around 900 people diagnosed here each year. In a small number of people these cells may develop into oesophageal cancer over time.

Northern Ireland has the only population register in the world of everyone in the country who has been diagnosed with Barrett's oesophagus and this data will form the basis of her study.

Dr Coleman will investigate the impact of new endoscopic methods that have been introduced to monitor and treat Barrett's oesophagus.

Previously the only potential intervention for early change in Barrett's cells, called dysplasia, was surgery, which was considered an extreme measure for patients with early changes who might never develop cancer, but in the past few years new techniques have enabled altered cells to be removed during endoscopic investigations.

Dr Coleman will study whether the availability of these new treatments has meant that doctors are now more likely to accurately diagnose dysplasia in Barrett's patients, and therefore potentially prevent more patients from developing oesophageal cancer.

She will also look at the effects of lifestyle factors including smoking, alcohol and nutrition, as well as the use of medications such as aspirin on the survival of oesophageal cancer patients after completing common treatments like chemotherapy and surgery. Dr Coleman explained: "Oesophageal cancer is difficult to treat because around three quarters of cases are diagnosed at a late stage."

She added: "It's fantastic to be selected for this career defining award and I am excited about working to find new ways to help prevent this cancer and new treatments to help patients survive for longer.

"Belfast is the leading centre in this kind of large population study and I believe that our work can really make a difference to patients' lives."

Dr Coleman will work with data from the UK-wide Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) Consortium, which includes patients from Northern Ireland, for this part of the research.

Sean Lennon (68), from Portaferry, Co Down, is an uncle of Dr Coleman's husband. In 2010 he noticed he was having difficulty swallowing food and visited his GP. He was later diagnosed with oesophageal cancer and underwent chemotherapy and surgery to successfully remove a tumour in April 2011.

Mr Lennon said: "I noticed that food was not going down properly and visited the doctor who referred me for a dye test and endoscopy which confirmed cancer of the oesophagus. Although it was a big shock, I feel fortunate that it hadn't spread into my stomach, so I know I did the right thing by acting quickly when I noticed changes in my swallowing, and I received excellent care throughout my treatment.

"It was a big operation, but I'm delighted to have responded so well to my treatment and to be able to enjoy life again.

"I'm so pleased that money is being invested in research in this area to help people who are affected by oesophageal cancer."

Last year Cancer Research UK spent around £16m on Oesophageal Cancer research in the UK while over £2m was spent on cancer research in Northern Ireland.

Belfast Telegraph


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