Police handed out £11,000 in fines after a number of parties were held in Belfast's Holyland on Monday night.
Officers visited seven addresses in the student area, with large numbers of young people gathering in the streets, some playing loud music and drinking.
A total of 55 Covid 4 fines, starting at £200, were issued, alongside 19 Covid 2 notices for holding a gathering.
Three people aged under 18 received community resolution notices and one 16-year-old was brought home to their parents.
Police have begun preparing files to be forwarded to the Public Prosecution Service over 14 people previously fined for breaking the regulations.
Residents campaigner Brid Ruddy said she was not surprised at the fines because there were "parties everywhere".
"It was really bad. It has been from last year, but last night was particularly bad. It was a Monday night. It's ridiculous," she added.
"We're talking an average of 10 to 15 parties a night in the middle of a pandemic. It's outrageous."
Mrs Ruddy, who has lived in the area for decades, said residents "have not got high expectations" ahead of St Patrick's Day.
She criticised inter-agency responses to the problem as falling short of what was needed.
"Quite frankly, nobody is listening. What are they doing to stop this? The other issue is the parents. What do they think young people are doing when there's no lectures?" she asked.
Mrs Ruddy told this newspaper residents had written to the First and Deputy First Minister but had not received a response.
"We thought Covid would break this pattern. If a pandemic can't stop it, what will?" she said.
Residents "dread to think what will happen when the pandemic ends and the new term starts," the campaigner stressed.
The Alliance Party's Paula Bradshaw said the police were to be applauded for their proactive response to the latest parties.
She said residents had been "tortured", with the situation deteriorating when students returned after Christmas.
"It does seem like costly fines are the ones that really focus their minds in terms of straightening out their behaviour," the South Belfast MLA said.
"Nobody is above the law. It's unfortunate, but these young people are well-educated and have the capacity to understand they can't breach regulations.
"It's lamentable it has got to the stage where they could be facing criminal records, but we have to protect the wider public."
PSNI Chief Inspector Gavin Kirkpatrick said police were increasing resources in the area ahead of St Patrick's Day.
"It is disappointing and difficult to understand how some people think the current health regulations and restrictions do not apply to them" he explained.
"It is apparent that some parents and guardians need to take more of an interest in what their young people are doing. This is a residential area. Understandably, local people are fed up having to live with this type of behaviour."
Belfast City Council said it was working with its partners in the area to prevent problems ahead of St Patrick's Day.
The news came as the PSNI confirmed that since the start of the pandemic, it had handed out 2,101 Covid 1 and 3,441 Covid 4 penalty notices for breaching lockdown regulations. More than 140 penalty notices were issued this week alone.