500 jobs created in triple coup
Around 500 jobs are to be created in Ireland with the expansion of three companies, it has been announced.
The pharmaceutical, technology and financial services roles will be based at separate operations in both Dublin and Shannon.
Alexion, which develops therapies for patients with severe and life-threatening rare disorders, said it will take on 200 workers at its new global supply headquarters in the capital.
The 75 million euro (£62 million) development at College Park in Blanchardstown is expected to create a further 200 construction jobs during the building of the site over the next three years.
Taoiseach Enda Kenny described the investment as a vote of confidence in the country.
"It is also hugely significant that the company - recognised by Forbes as the world's second most innovative - has chosen to establish operations in the country it recognises as the best in the world for business," he said.
Planning permission has been granted for a 15,000 square metre laboratory, office, packaging and warehouse facility on the 41-acre greenfield site at College Park. It is due to open in 2017.
Alexion said it will take on the new staff by 2016 in a number of roles including supply chain, quality control, warehousing and support.
The company already employs more than 60 people at its Park West plant in Dublin. Earlier this year, it announced plans to acquire a second site in Athlone to create a factory for bottling medicines.
Leonard Bell, chief executive of Alexion, said Ireland is a key location for its global supply operations.
"Our choice of Ireland reflects the calibre of the workforce and the country's culture of innovation, and we look forward to an ongoing partnership with the Irish Government, IDA Ireland and local communities in the years to come," he said.
With headquarters in Connecticut in the US, Alexion has more than 1,800 staff in nearly 50 countries.
Ryanair said it is looking for 200 employees to work in technology, software development and digital marketing roles at its new offices at Airside Business Park in Swords, north Dublin.
Recruits are needed to work on the airline's digital platform and mobile app.
Separately, financial services company Pepper Asset Servicing said it is creating 100 jobs in Shannon and Dublin.
It is hiring financial services specialists with experience in mortgage arrears, customer services, real estate and legal affairs over the coming year.
The firm said the expansion was down to new contracts with CarVal Investors, Danske Bank and the National Asset Management Agency (Nama).
Paul Doddrell, chief executive of Pepper Asset Servicing in Ireland, said its ambition is to grow the company and take on more people.
"The additional significant investment in our Shannon office in particular reaffirms Pepper's commitment to further grow its operations in Ireland, and in this context Pepper offers a unique opportunity to work with significant indigenous and international clients and to be part of a global company with exciting growth plans for the future," he said.
The company, only set up a year and a half ago, invested two million euro on new systems and office facilities over the last year.