Up to 200 jobs are being created with the expansion of a medical devices company.
VistaMed said it is investing 10 million euro in a new research and development plant in Carrick-on-Shannon.
Manufacturing at the site will also be expanded.
VistaMed makes catheters for medical use.
The new roles will take the number of people employed by the company in Co Leitrim to 525 .
Recruitment has started already and VistaMed said all the positions are expected to be filled by the end of 2018.
Jobs Minister Mary Mitchell O'Connor said the latest expansion of the home-grown company is evidence that a rural county such as Leitrim can be home to successful international companies.
"To announce 200 jobs for an Irish-owned, highly innovative, global supplier of medical technology out of County Leitrim, sums up why we can be ambitious - indeed, must be ambitious - in our plans for regional development and job creation," she added.
The company was founded in 1999.