More than 500 jobs are being created in two major investments.
In the first, c loud computing giant Oracle is to hire 450 staff in Dublin as expands its operations with new state-of-the-art offices on the Eastpoint business park.
The second will see 70 jobs created over the next 18 months by 3D4Medical, an Irish medical technology company which is one of the world leaders in developing applications for the healthcare sector.
Taoiseach Enda Kenny and Jobs Minister Richard Burton, as well as officials from IDA Ireland which has supported the Oracle investment, were given a tour of the company site as the announcements were made.
T he investment is part of the cloud firm's international recruitment to find 1,400 sales people to drive its growth in Europe, the Middle East and Africa, with Dublin chosen alongside Amsterdam, Cairo, Dubai, Malaga and Prague.
Oracle president Loic Le Guisquet said: "These are exciting times for Oracle. We are extending our sales force to support our customers through their digital transformation.
"I want socially-savvy, switched-on individuals who can help customers respond to the digital imperative and make their businesses future-proof. We're looking for people who want to be relevant to the biggest trends shaping business and technology."
Oracle has more than 600 different cloud applications which, combined with what it calls comprehensive on-premise hardware and software, helps clients seamlessly manage their computing environment and switch to the cloud.
3D4Medical, which is being supported by Enterprise Ireland, revealed its recruitment plan to treble its workforce as it opened a new global headquarters in Blackrock, Dublin.
The home-grown company specialises in developing medical applications for professional reference as well as student and patient education for use on the iPhone, iPad and on desktops.
It also has offices in Poland, Russia and San Diego.