DJ Calvin Harris has pulled out of tomorrow's MTV European Music Awards due to illness.
Organisers said Harris will no longer perform at the star-studded show at Glasgow's SSE Hydro on Sunday night.
U2, Alicia Keys and Ed Sheeran are set to play at the awards hosted by US rapper Nicki Minaj.
A message on the MTV EMA Facebook page said: "W e have some really sad news. Calvin Harris has taken ill and will not be able to perform at tomorrow's show. He sends his sincere apologies. Get well soon, Calvin!"
With nominations across seven categories, Katy Perry leads the award competition this year, closely followed by Ariana Grande with six.
Pharrell Williams is up for five trophies, including best song and best video for his global hit Happy.
MTV held castings for more than 2,000 local music fans to be part of the audience for the show, which will be broadcast live on MTV channels at 8pm.
Enrique Iglesias, Kiesza and Royal Blood will also perform at the ceremony, which organisers said will have a time travel theme.
Guitar legend Slash and actor David Hasselhoff will present trophies, while Black Sabbath icon Ozzy Osbourne will be present to receive the EMA's Global Icon Award.
Grammy award-winning singer Alicia Keys is one of several artists to be nominated in a new category, Best Song with a Message, for her song We Are Here.
She said: "I am crazy excited to perform on the global stage of the EMA and for my song to be nominated.
"We Are Here is a 21st century peace movement that believes if we all stand together and join our voices we can create a kinder world for everyone."
Keys's performance will take place in front of an audience at Glasgow's O2 Academy and be beamed live into the SSE Hydro.
The O2 hosted Biffy Clyro and former Guns N' Roses guitarist Slash at a pre-show event yesterday.
Slash told organisers: "Scotland's just beautiful, I love it here. I've got a lot of good memories playing this city."
The awards are being held in Glasgow for the first time in their 20-year history.
Tourism chiefs say the global exposure could be worth up to £10 million to the Scottish economy.