A doctor, sister and staff nurse have been charged with gross negligence manslaughter over the death of a six-year-old boy who died in hospital in 2011.
The Crown Prosecution Service said it had taken the decision to charge over the death of Jack Adcock, of Glen Parva, Leicestershire, only after careful consideration of the evidence.
Jack, who had Down's syndrome and other pre-existing health problems, died of pneumonia at Leicester Royal Infirmary on February 18 2011 after initially being admitted with sickness and diarrhoea.
Dr Hadiza Bawa-Garba, Sister Theresa Taylor and Staff Nurse Isabel Amaro are due to appear at Leicester Magistrates' Court on January 23 over the allegations.
Fiona Morrison, specialist prosecutor with the CPS's special crime division, said the decision to charge was made in light of a review of the evidence gathered by Leicestershire Police into the clinicians' "treatment and care" of the youngster.
She added: "Having completed our review, we have concluded there is sufficient evidence and it is in the public interest for Dr Bawa-Garba, Sister Taylor and Staff Nurse Amaro to each face charges of gross negligence manslaughter.
"The decision to prosecute has been taken in accordance with the Code for Crown Prosecutors."