Four men have been arrested on suspicion of sexually abusing a girl, police said.
Officers investigating child exploitation in Buckinghamshire arrested the men in the High Wycombe area, Thames Valley Police said.
The men, aged 19, 20, 21 and 22, are alleged to have committed "various sexual offences" against the girl and are currently in police custody.
Area commander Superintendent Gilbert Houalla said: "These arrests are a continuation of Operation Ribbon, which is an investigation that began last year into child sexual exploitation. This is not uncommon and one arrest often leads to others.
"I would like to assure you that the police in the Wycombe district will always protect the vulnerable and challenge any offenders without fear or favour, none of which could be done without the support of our community."
Thames Valley Police said they believe it is likely there are more victims who have not spoken to officers, and encouraged them to come forward by calling 01296 396396.
A spokesman said officers work closely with Buckinghamshire County Council's child protection team, and deal with each case with respect and confidentiality.
Anyone worried about somebody who may be a victim of child exploitation can call the ChildLine charity on 0800 1111 or visit its website, www.childline.org.uk, the force said.
People can also call Buckinghamshire County Council's First Response Team on 0845 4600 001 if they have any concerns around child sexual exploitation.
If they do not want to speak to police they can call the Crimestoppers charity anonymously on 0800 555 111.