Boris Johnson is set to join scientists from Kew Gardens in a bid to secure world heritage site status for the Singapore Botanic Gardens on the latest stop of the London Mayor's regional tour.
Mr Johnson will visit the garden before flying on to Jakarta, Indonesia, on the third day of the six day visit to south east Asia.
The Singapore venue contains an orchid garden dedicated to the late Margaret Thatcher and was recently visited by the Duke and Duchess of Cambridge.
Kew Gardens played a key role in the establishment of the 74-hectare garden when in 1877 a batch of 22 Para Rubber seedlings was sent to Singapore, paving the way for the rubber industry of the region.
Mr Johnson said: "Singapore's relationship with one of our most quintessentially British brands is testament to the huge appetite there is for London's expertise overseas.
"The outstanding hard work of London's world-renowned Kew Gardens, to nurture and develop other botanical and scientific centres across the globe, has been benefiting its younger cousin here in Singapore for almost 150 years.
"Partnerships like these, as they continue to flourish, are enhancing London and the UK's reputation around the world, and will go on driving jobs and growth in the capital for many centuries to come."
Kew Gardens director Richard Deverell said: "The Royal Botanic Gardens, Kew, has an international reputation as the global resource for plant knowledge.
"Based in Greater London it is part of the city's cutting edge knowledge economy. Kew is looking forward to working even more closely with the Singapore Botanic Gardens, through science, conservation and horticultural collaborations."
Singapore's first bid for a Unesco World Heritage Site began with the submission of the Singapore Botanic Gardens' official nomination dossier to Unesco in February this year.
Unesco's decision on Singapore Botanic Gardens' nomination could be reached by June 2015.