Police are being given extra time to question a man suspected of murdering missing schoolgirl Alice Gross.
Two men with no connection to each other remain in custody in a west London police station after the 14-year-old went missing at the end of last month.
Detectives with the Metropolitan Police, who have successfully applied for more time to question the first suspect, said the girl's disappearance remains a missing persons inquiry.
A 25-year-old man has been in custody since his arrest on Saturday, while a 51-year-old man was arrested yesterday evening in the schoolgirl's home area of Hanwell, west London. Both are being held on suspicion of murder.
A Met spokesman said: " All lines of inquiry are still open and this remains a missing person investigation at this stage."
Alice, who has anorexia, went missing 12 days ago after she left her home in the afternoon but failed to return.
She was last seen by her family at 1pm on August 28, and was captured on CCTV at 4.23pm that day walking along the Grand Union Canal near her home.
Specialist police divers in black wetsuits and breathing apparatus have been combing the west London waterway where she was last spotted.
Sniffer dog handlers with a golden Labrador have taken to the canal on a red dinghy boat to scan it for evidence.
Police have trawled through hundreds of hours of CCTV footage and carried out "extensive" searches using specialist officers in the hunt for the missing schoolgirl.
Alice is white, 5ft 2ins tall, of very slim build and with shoulder-length, light brown hair.
She was last seen wearing dark blue jeans and a dark green lacy cardigan and carrying a dark rucksack, which was recovered last week. She may have been wearing denim blue Vans shoes and tartan-framed spectacles.
Police said they were "especially concerned" as Alice has not been well recently.
Officers are also urging anyone who may have befriended Alice while on a song-writing workshop at the Camden Roundhouse to come forward.
Last week Alice's mother, Rosalind Hodgkiss, issued an appeal to help find her daughter.
She said: "We'd like to say to Alice first of all that we miss her, that we love her and that she's not in any trouble, and we want to know that she's safe. We just want her to come home.
"We're also appealing to anybody who might have seen her or who may have made contact with her or who may know something about her whereabouts to contact police or Missing People, and to just get in touch because we're really concerned about her wellbeing."
Surrey and Sussex Police have both provided specialist resources to the Met to help with their search.
Anyone with information can call police on 020 8358 0100, Ealing Missing Persons Unit on 020 8246 1018 or the charity Missing People on 116000.