New database to help tackle antibiotic resistance threat
It is hoped the database will encourage scientists to investigate ‘forgotten antibiotics’.
Scientists are launching a database to help encourage the development of new antibiotics.
Researchers have developed the new tool to help list compounds that could be used to develop novel drugs.
It comes amid global concern that some drugs used to fight infections are losing effectiveness.
It has previously been estimated that if no action is taken, drug-resistant infections will kill 10 million people a year by 2050.
A new paper outlining the new database, published in the Journal of Antimicrobial Chemotherapy, states: “The current state of antibiotic discovery, research and development is insufficient to respond to the need for new treatments for drug-resistant bacterial infections.”
The database, AntibioticDB, comes after a collaboration between the University of Birmingham, the John Innes Centre and the British Society for Antimicrobial Chemotherapy.
We have developed and populated an easy-to-use database of antibiotics that can be accessed for free by anybody; we hope this will help both academia and commercial companies with their drug-discovery efforts Professor Laura Piddock, lead author
It details antibacterial compound discoveries that were once-promising leads but, for various reasons, the research has stopped or stalled.
Lead author Professor Laura Piddock, of the University of Birmingham’s Institute of Microbiology and Infection, said: “There is no doubt that the antibiotic pipeline needs revitalisation; however, the answer may be not only the development of new drugs, but also reinvestigating compounds previously discontinued.
“For this reason, we have developed and populated an easy-to-use database of antibiotics that can be accessed for free by anybody; we hope this will help both academia and commercial companies with their drug-discovery efforts.”
Professor Tony Maxwell, of the John Innes Centre, said: “We wanted to establish the current status of the drug-discovery pipeline in antibiotic development – particularly to look at compounds that might have been dropped in the past to see if they could be resuscitated.
“We also went back to 1960 and uncovered details of old compounds and drugs that were not developed. These could form the basis for new development to treat today’s infections.”
It would be fantastic if the database could stimulate new initiatives to investigate forgotten antibiotics Rebecca Lo, post-graduate researcher
Rebecca Lo, a post-graduate researcher from the University of East Anglia, who carried out work on the project while she was an intern at the John Innes Centre, added: “It would be fantastic if the database could stimulate new initiatives to investigate forgotten antibiotics.”
In recent years, there has been a UK drive to raise global awareness of the threat posed to modern medicine by antimicrobial resistance.
If antibiotics lose their effectiveness, then key medical procedures – including gut surgery, caesarean sections, joint replacements and chemotherapy – could become too dangerous to perform.
Health leaders from around the world have raised serious concerns about the growing resistance to antimicrobial drugs.
These are the drugs which destroy harmful microbes.
Antibiotics are the best known of these drugs, but there are others – such as antivirals, antimalarial drugs and antifungals.