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New model of Covid-19 spike protein ‘could help vaccine development’

Researchers in Germany said their work has helped identify target sites on the spike protein’s surface for antibodies.

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Patches of intense purple at the surface of the spike protein indicate potential target sites for antibodies that are not protected by the glycans, shown in green (Mateusz Sikora/PA)

Patches of intense purple at the surface of the spike protein indicate potential target sites for antibodies that are not protected by the glycans, shown in green (Mateusz Sikora/PA)

Patches of intense purple at the surface of the spike protein indicate potential target sites for antibodies that are not protected by the glycans, shown in green (Mateusz Sikora/PA)

New vulnerable sites on the surface of the Covid-19 spike protein have been identified by scientists who say their work could help in the development of vaccines.

Coronavirus is studded with spike proteins that it uses to enter human cells.

Covid-19 vaccines work by teaching the immune system to make antibodies to the spike protein.

Researchers in Germany have developed a detailed model of the spike protein to identify potential target sites on its surface for the antibodies.

Our approach can support the design of vaccines and therapeutic antibodies, especially when established methods struggleResearcher Mateusz Sikora

They said previous models have not shown the flexibility of the spike protein or the movements of the protective glycans – which they describe as chains of sugar molecules – that coat it.

The team, from the Max Planck Institute of Biophysics in Frankfurt, said the glycans help the virus evade a person’s immune system by moving back and forth in a motion they likened to car windscreen wipers.

The researchers said their simulations, published in the PLOS Computational Biology journal, allowed them to identify spots on the surface of the spike protein that are least protected by the glycan “shields”.

While some of the sites detected were known from previous research, the team said they managed to identify some new ones.

Researcher Mateusz Sikora said: “We are in a phase of the pandemic driven by the emergence of new variants of SARS-CoV-2 (the coronavirus that causes Covid-19) with mutations concentrated in particular in the spike protein.

“Our approach can support the design of vaccines and therapeutic antibodies, especially when established methods struggle.”

PA


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