The Duke of Cambridge will call on President Barack Obama during his visit to America with the Duchess.
The two men will meet at the White House in Washington on Monday ahead of a major speech William will deliver, expected to be about the illegal wildlife trade, at the World Bank Group's International Corruption Hunters Alliance Conference.
William and Kate will travel to the US on Sunday for a three-day visit, spending the majority of their time in New York, where they will promote their charitable interests and other good causes.
The Duke will be following in the footsteps of his father, the Prince of Wales, who chatted to Mr Obama in the White House's Oval Office in May 2011.
The US leader famously told Charles that America had been mesmerised by William and Kate's wedding a few days earlier.
President Obama and his family have developed a close affinity with the British monarchy during his term in office.
When the Queen hosted the US leader and his wife, Michelle, at Buckingham Palace during a state visit in 2011, the First Lady was seen putting her arm around the monarch's waist, showing how the women had become firm friends.
William and Kate also met the Obamas during their official visit and chatted to them in the sumptuous surroundings of the Palace's 1844 Room.
While William is attending events in Washington, Kate will join the first lady of New York City, Chirlane McCray, on a visit to a local child development centre.
During their brief trip to the US, the Duke and Duchess will attend events in support of their Royal Foundation and other organisations.
The engagements include promoting sustainable conservation issues, young people's mental health and supporting disadvantaged young people.