President Bashar Assad has rejected US accusations that Syrian or Russian planes struck an aid convoy in Aleppo or that his troops were preventing food from entering the city's rebel-held eastern neighbourhoods, blaming the US for the collapse of a ceasefire many had hoped would bring relief to the war-ravaged country.
In an interview with The Associated Press in Damascus, Mr Assad also said deadly US air strikes on Syrian troops last week were intentional, dismissing American officials' statements that they were an accident.
Mr Assad said the US lacked "the will" to join forces with Russia in fighting extremists.
Mr Assad, who inherited power from his father and is now in his 16th year in office, cut a confident figure during the interview -a sign of how his rule, which once seemed threatened by the rebellion, has been solidified by his forces' military advances and by the air campaign of his ally Russia, which turned the tables on the battlefield last year.
He said his enemies alone were to blame for nearly six years of devastation across Syria, and while acknowledging some mistakes, he repeatedly denied any excesses by his troops. He said the war was only likely to "drag on" because of continued external support for his opponents
"When you have many external factors that you don't control, it's going to drag on and no one in this world can tell you when" the war will end, he said, insisting Syrians who fled the country could return within a few months if the US, Saudi Arabia, Turkey and Qatar stopped backing insurgents.
He spoke on Wednesday in Damascus' Muhajireen palace, a white-stone building where he often receives guests, nestled among trees on the foothills of Qasioun Mountain. The Syrian capital, seat of Assad's power, has stayed relatively untouched throughout the conflict, spared the devastation inflicted on other, opposition-held areas of the country. In recent months, Mr Assad's forces have taken rebel strongholds in suburbs of the capital, bolstering security and reducing the threat of mortar shells.
The attack on the aid convoy outside Aleppo took place on Monday night, hitting a warehouse as aid workers unloaded cargo and triggering huge explosions. Footage filmed by rescuers showed torn flesh being picked from the wreckage. Witnesses described a sustained, two-hour barrage that included barrel bombs - crude, unguided explosives that the Syrian government drops from helicopters.
A senior US administration official said the US believes with a very high degree of confidence that a Russian-piloted aircraft carried out the strike.
Mr Assad dismissed the claims, saying whatever American officials say "has no credibility" and is "just lies".
Like Syria, Russia has denied carrying out the convoy bombing.
Syria and the United States have been at loggerheads since the September 17 US air strike last week that hit Syrian troops in the eastern province of Deir el-Zour.
US officials said the attack - its first direct hit on Syrian forces since the civil war began - was accidental and that the warplanes thought they were targeting Islamic State group positions. Russia said the strikes killed more than 60 Syrian troops, and afterwards, IS militants briefly overran government positions in the area until they were beaten back.
Mr Assad said he did not believe the American account and said that attack targeted a "huge" area constituting many hills.
"It wasn't an accident by one airplane... It was four airplanes that kept attacking the position of the Syrian troops for nearly one hour, or a little bit more than one hour," Mr Assad said in the interview. "You don't commit a mistake for more than one hour."
"How could they (IS) know that the Americans are going to attack that position in order to gather their militants to attack right away and to capture it one hour after the strike?" Mr Assad asked. "So it was definitely intentional, not unintentional as they claimed."
A spokesman for the US State Department dismissed Mr Assad's claims as "ridiculous", adding that they underline that Mr Assad has lost his legitimacy to govern.
"It's difficult to see how these ridiculous claims deserve a response, except to say they prove yet again the degree to which Mr Assad has lost his legitimacy to govern and how vital it remains for the international community to achieve a political solution that gives the Syrian people a voice in their future," spokesman John Kirby said on Thursday.
The strikes contributed to the collapse of the ceasefire, which had already been marred by numerous violations on both sides of the conflict. They also cast serious doubt on chances for implementing an unprecedented US-Russian agreement to jointly target militants in the country.
Mr Assad said the United States lacked the will to work with Russia against extremists in Syria. "I don't believe the United States will be ready to join Russia in fighting terrorists in Syria," he said.
Despite extensive evidence to the contrary, Mr Assad repeatedly denied that his forces were besieging opposition-held eastern Aleppo, which has become a symbol both of resistance and also the high price civilians are paying in the war.
He flatly denied claims of malnutrition and a chronic lack of medical supplies.
"If there's really a siege around the city of Aleppo, people would have been dead by now," Mr Assad said, asking how rebels were able to smuggle in arms but apparently not food or medicine.
The ancient city, now partly destroyed, has been carved out into rebel and government-controlled areas since 2012. Rebel reinforcements broke a hole in the blockade in August. But in heavy bombardment over the following weeks, more than 700 civilians were killed. Earlier this month, Syrian troops backed by Russian airstrikes retook the roads and the siege resumed.
Since then, the UN has accused Mr Assad's government of obstructing aid access to the city, despite an agreement to allow aid in during the weeklong ceasefire. During the brief ceasefire, trucks carrying aid sat idle by the nearby Turkish border, awaiting permits and safety guarantees.
Throughout the conflict, MrAssad's forces have been accused of bombing hospitals and civilians and choking opposition cities. Millions have fled Syria, some of them drowning at sea in the Mediterranean.
The war has been defined by gruesome photos and video posted in the aftermath of bloody attacks or documenting the plight of children in particular. Hundreds of thousands of people have been killed, and once thriving cities have been ravaged, with entire blocks reduced to rubble. The images have galvanised public opinion worldwide - but Mr Assad, while acknowledging that the war had been 'savage', said eyewitness accounts should not be automatically believed.
"Those witnesses only appear when there's an accusation against the Syrian army or the Russian (army), but when the terrorists commit a crime or massacre or anything, you don't see any witnesses... So, what a coincidence," he said.
Mr Assad scoffed at the idea that Syria's "White Helmets" - civil defence volunteers in opposition held areas seen by many as symbols of bravery and defiance - might be considered for a Nobel Peace Prize after a nomination earlier this year.
"What did they achieve in Syria?" he said. "I would only give a prize to whoever works for the peace in Syria."
The group shared this year's Right Livelihood Award, sometimes known as the "Alternative Nobel," with activists from Egypt and Russia and a Turkish newspaper, the prize foundation announced on Thursday.
Asked about his methods, including the use of indiscriminate weapons, Mr Assad said "when you have terrorists, you don't throw at them balloons, or you don't use rubber sticks for example. You have to use armaments."