Donald Trump has said his first foreign trip as US president will feature stops in Saudi Arabia, Israel and the Vatican, where he will meet Pope Francis.
The foray on to the world stage will also include meetings with Nato and a summit in Italy.
Senior administration officials said Mr Trump chose Saudi Arabia as his first stop to show his commitment to improving US relations with the Muslim world.
Mr Trump will meet Saudi Arabia's King Salman and other leaders where they are expected to discuss efforts to defeat terrorism and discredit radical ideologies, the officials said.
Mr Trump, joining religious leaders in the Rose Garden on Thursday, said his first foreign trip would "begin with a truly historic gathering in Saudi Arabia with leaders all across the Muslim world".
"Saudi Arabia is the custodian of the two holiest sites in Islam and it is there that we will begin to construct a new foundation of co-operation and support with our Muslim allies to combat extremism, terrorism and violence and to embrace a more just and hopeful future for young Muslims in their countries," Mr Trump said.
The week-long trip will mark the president's first trip abroad and come about six weeks after the US launched Tomahawk missiles against a Syrian air base in the aftermath of a chemical weapons attack in the war-ravaged country.
The trip will inject Mr Trump into the thorny quest for Middle East peace, a prospect that has proven elusive for his predecessors.
The announcement follows Mr Trump's meeting on Wednesday with Palestinian leader Mahmoud Abbas and his optimistic pledge to mediate peace efforts between the Israelis and the Palestinians.
Mr Trump has sought to forge strong ties with Israel's Prime Minister Benjamin Netanyahu at the start of his presidency in the hopes of facilitating peace.
The visit to Israel will reinforce that alliance, officials said.
"Our task is not to dictate to others how to live but to build a coalition of friends and partners who share the goal of fighting terrorism and bringing safety, opportunity and stability to the war-ravaged Middle East," Mr Trump said.
The Palestinians want to create a state in the West Bank, Gaza Strip and east Jerusalem, lands Israel captured in the 1967 Middle East war.
Mr Abbas noted that demand when he joined Mr Trump at the White House.
But Mr Netanyahu has rejected the 1967 frontier as a baseline for border talks and ruled out partitioning Jerusalem, where Palestinians hope to establish a capital.
Mr Netanyahu's government has expanded settlements despite US efforts to curb the construction.
The White House had said previously that Mr Trump would travel to Belgium for the Nato meeting and Italy for the G7 summit before Memorial Day.
The president previously called Nato "obsolete" but has since recanted after listening to European leaders make the case for the military alliance.
Mr Trump will be making his first overseas trip late into the start of his presidency compared with his predecessors.
Former president Barack Obama had visited nine countries by late April 2009, his first three months in office, meeting with allies such as Canada, Britain and Germany.
The last first-term president to wait until May to venture abroad was Jimmy Carter in 1977.
His visit will also give him the opportunity to connect with Roman Catholics with his visit to see Pope Francis at the Vatican.
The White House said the president met privately on Thursday with Roman Catholic cardinals.
Mr Trump and Francis could not be more different in their approaches to some of the pressing issues of the day, with immigration and climate change topping the list.
Francis has spoken of the need for bridges between nations, not the walls that Mr Trump has called for.
He has called for an end to the use of fossil fuels, while Mr Trump has pledged to cancel payments to UN climate change programmes and pull out of the Paris climate accord.
But both share a populist appeal and speak with a down-to-earth simplicity that has endeared them to their bases of supporters.
And both share a common concern about the plight of Christians in the Middle East at the hands of Islamic militants.
Francis recently called for the US and North Korea to step away from the brink and use negotiations and diplomacy to defuse tensions on the Korean peninsula - an issue that is likely to feature in any Vatican audience.
During the campaign, when asked about Mr Trump's border wall with Mexico, Francis famously said anyone who wants to build a wall is "not Christian".
Mr Trump shot back that it was "disgraceful" for a religious leader to question someone's faith.