Jeb Bush ended his campaign for the presidency after a disappointing finish in South Carolina, acknowledging his failure to harness the hopes of Republican voters angry at the political establishment.
The former Florida governor told supporters that he had tried to stay true to what he believes.
Still, he was lagging far behind in the primary in South Carolina, where his well-organised campaign was outmatched by insurgent billionaire Donald Trump, and senators Ted Cruz and Marco Rubio.
"I'm proud of the campaign that we've run to unify our country and to advocate conservative solutions," a visibly emotional Mr Bush said.
"The presidency is bigger than any one person. It's certainly bigger than any one candidate.
"I firmly believe the American people must entrust this office to someone who understands that whoever holds it is a servant not the master."
The son of George HW Bush and brother of George W Bush entered the race to huge expectations in June, and quickly fuelled them with fundraising.
Working with a outside funding group that has supported his candidacy, Mr Bush and allies raised more than 150 million dollars (£104 million) by the end of 2015 - far more than any of his Republican rivals.
However, Mr Bush's presence in the race and fundraising potential was not enough to dissuade more than a dozen other Republicans from entering the race, including fellow Floridian, Mr Rubio.
Mr Bush's failure to ignite was not simply a factor of the size of the Republican field. He, like others, was caught off-guard by the durable popularity of political outsiders - particularly Mr Trump.
The final stage of Mr Bush's campaign became an all-out fight with the outspoken real estate mogul - the two frequently referring to each other as a "loser".
Mr Bush attacked Mr Trump's lack of experience, and the billionaire focused on the Bush family legacy, particularly the unpopular Iraq war waged by his brother.
Mr Bush offered himself as an experienced public executive and potential world statesman informed in part by his father's and brother's wartime presidencies.
But it was not a case strong enough to translate into votes.
There were other problems as well. The policy-oriented Mr Bush was overshadowed in early debates by Mr Trump and Mr Rubio, which dramatically slowed his early autumn fundraising.
Mr Bush went on to finish sixth in the Iowa caucuses, and barely squeezed ahead of Mr Rubio in New Hampshire for a fourth place finish.
South Carolina was viewed as a last chance for Mr Bush to make a mark.
Having previously kept his family ties at arm's length, he brought them to the forefront ahead of South Carolina.
His father and brother both won the South Carolina primary when they were seeking the presidency, and he had set his hopes high there for a campaign revival.
Despite support for the Bush family among a segment of devoted South Carolina Republicans, Mr Bush himself had a halting final week of campaigning.
At a Wednesday town hall meeting in Summerville he was offered more advice than policy questions, the same day he learned South Carolina governor Nikki Haley had endorsed Mr Rubio.