David Haye's dream of regaining the world heavyweight title looks over as the Londoner faces retirement due to a shoulder injury.
The Londoner has pulled out of his rescheduled fight with Tyson Fury on February 8 next year and looks set to end his career permanently after an unsuccessful operation last week.
"It's a crushing blow for me," he said.
"I had big plans for next year and the ultimate goal was to win back the world heavyweight title, something my amazing fans deserve.
"What I didn't anticipate was that this year would be the unluckiest of my career and that a number of injuries would disrupt my plans so much.
"Perhaps it just wasn't meant to be. The boxing gods keep hinting that maybe enough is enough and that it's time to finally hang up my gloves."
Meanwhile, Ryan Burnett was the pick of the Northern Ireland boxers who had mixed fortunes at the weekend.
Unbeaten Belfast bantamweight Burnett was too slick for Spain's Sergio Perez in Bulgaria, winning clearly on points in their six-rounder.
Burnett floored the Spaniard in the second round and from then on he controlled the action.
The 21-year-old Olympic Youth gold medallist will look to make it five out of five when he returns to the ring on December 14 in Wigan.
Belfast lightweight Sonny Upton lost on points to journeyman Goga Koshkelishvilli on his debut at the same show as he
Former Commonwealth heavyweight champion Martin Rogan was knocked out cold in the first round by unbeaten German Erkan Teper at in Germany.
In Australia, welterweight Patrick Murphy was a points winner over Aussie Adrian Campbell.