England will be without their Indian Premier League stars at Malahide on May 3 in the one-off one-day international which starts Ireland's summer.
Although Moeen Ali, Ben Stokes, Johnny Bairstow, Jos Buttler and Chris Woakes will all play in the five-match one-day series against Pakistan , which starts five days later, and are certainties for the World Cup squad, they have been 'rested' for England's first visit to Ireland in four years.
Eoin Morgan will lead a 14-man squad which includes the uncapped pace bowler Jofra Archer, who will be having an audition before the World Cup favourites name their final 15-man squad on May 19.
Barbados-born Archer only qualified for England last month through his residency but the 24-year-old Sussex bowler has been on their radar for some time because of his genuine pace and outstanding athleticism in the field.
With Mark Wood, another 90mph bowler, also in the squad, the Ireland batsmen will face a white-hot examination and although three 'gun batsmen' in Bairstow, Buttler and Stokes will be missing, the power of Alex Hales, Jason Roy and Morgan, plus Test captain Joe Root, will be on show.
There are still six survivors from the 2015 match in Hales, Roy, James Vince and Adil Rashid plus Wood, who bowled Ireland captain William Porterfield, and David Willey, who claimed the wicket of Andrew Balbirnie on his debut as Ireland slumped to 56-4.
England also named a provisional 15-man World Cup squad, as per ICC requirements, yesterday but impressive performances by Sam Billings, Vince, Jordan and, of course, Archer can yet force their way into the final 15.
Jack Tector could yet make the Ireland squad for the match next month after the uncapped YMCA opening batsman hit two more half-centuries as the Ireland Academy side finished their English tour with five wins out of five.
Having already hit 94 not out in the opening 50-over game against Bath CC, Tector made 82 not out from 85 balls against an England Development XI at Rockhampton on Tuesday and followed up with an undefeated 69 yesterday against Gloucestershire II as the Academy side won by nine wickets.
Jarred Barnes, the former Coleraine, Muckamore and Armagh pace bowler, took his second five-wicket haul of the tour in Tuesday's six-wicket victory, finishing with 5-23 as the England side were bowled out for 171.
Tector will get a chance to enhance his claims with Leinster Lightning next week when the Inter-provincial One-day Cup series gets under way with the first three games in La Manga.
England squad (to face Ireland): E Morgan (capt), J Archer, S Billings, T Curran, J Denly, C Jordan, A Hales, L Plunkett, A Rashid, J Root, J Roy, J Vince, D Willey, M Wood.