James Anderson is forced to wait for Ian Botham's Test record
James Anderson is still one short of Sir Ian Botham's England record of 383 Test wickets as West Indies finished day four on 98-2, chasing a target of 438.
West Indies need to score 340 more runs to win.
Stuart Broad made the early breakthrough as West Indies began their unlikely pursuit of 438 in the first Test, with Anderson's pursuit of a place in the history books set to continue.
England declared on 333 for seven in the middle session, with Gary Ballance's fourth Test century the cornerstone of a superb third innings effort.
Anderson, on the occasion of his 100th Test, took the new ball on 382 Test scalps, just one behind the milestone set by Sir Ian 23 years ago.
Broad got England's victory push moving when he bounced out Kraigg Brathwaite with his fifth delivery.
Ballance had laid the foundations with a fine 250-ball stay.
The 25-year-old had a torrid World Cup but picked up where he left off in the longer format, having scored three hundreds last summer.
England resumed on 116 for three, adding 217 in 48 overs, a run-rate of just over 4.5.
Ballance was assisted in no small part by Joe Root (59), Ben Stokes (35) and Jos Buttler (59no).