For different reasons, Conrad Cummings and Marc McCullough have reached a point where they are both having to weigh up their future in the sport.
Popular Coalisland man Cummings was left stunned by his fifth round stoppage loss to Essex man Danny Dignum in their WBO European middleweight title fight at the York Hall, Bethnal Green on Saturday night, while McCullough has revealed that his latest brain scan prevented him from boxing in the Ulster Hall last month.
Cummings, who suffered a second painful defeat at the hands of Luke Keeler earlier this year, had been aiming to bounce back with a victory over Dignum but in the fifth round he was tagged by a rasping left that had him out on his feet as referee Howard Foster stepped in to call a halt after 21 seconds of the round.
Having been stopped for the first time in his career, in a bout which he never looked like taking control of as he soaked up sharp right leads and uppercuts against an opponent he was expected to defeat, Cummings must now seriously consider if the time is right to call time on his career.
Cummings, to his credit, saluted the performance of Dignum for whom this was the most significant victory so far.
Meanwhile, Irish super-featherweight champion McCullough says he is waiting for the British Boxing Board of Control to report back on the results from a scan before he can decide if he has a future in the sport.
"I really don't know what is going to happen. I have been waiting to hear word from the British Boxing Board of Control to see what they have to say. Whatever comes back it's going to be a very tough decision to make," said McCullough.
McCullough's wife Fiona and coach Charlie Toland have made it clear they would prefer him to hang up his gloves.
"Charlie has just come straight out and told me that he doesn't care what the result is, he doesn't want to train me any more because it's just too dangerous and Fiona has been on at me, asking me if it's really worth going on," added McCullough, who had a fine win earlier this year when he stopped Declan Geraghty to win the Irish super-featherweight title.
He was then set to meet Romanian Viorel Simion in an international title bout knowing that victory could have led to a world title shot.
A full-time worker at Randox, the 29-year-old McCullough added: "It's a very tough business but I know it will be very hard to walk away if I have to."