Real Madrid made Roma pay for their wasted chances as they secured a place in the quarter-finals of the Champions League for the sixth season in a row with a 2-0 win at the Bernabeu.
The Italians needed to overturn a 2-0 deficit from the first leg, but created enough chances during the first-half to be at least on level terms as Edin Dzeko and Mohamed Salah both missed when clear through on goal.
Real eventually made the breakthrough when in-form Cristiano Ronaldo scored from close range after 64 minutes, with James Rodriguez adding a quick second to end any hopes of a recovery.
Roma came to Spain having won their last seven Serie A games under Luciano Spalletti.
Real Madrid named Gareth Bale in the starting XI for the first time since January 17 following his return from a calf injury.
The visitors started with some intent as right-back Alessandro Florenzi floated a cross across the Real area. It was not long before Real were on the front foot, with Bale getting away down the left to pick out Marcelo, but the defender slipped.
Roma wasted a great chance to go ahead on 14 minutes.
Salah worked the ball across from the right, allowing Dzeko in on the overlap, but the Bosnia striker could only stab wide.
Wojciech Szczesny produced a good save to palm away a deflected shot from Luka Modric.
Roma opened the home side up again when breaking quickly as Salah was played into the right side of the area.
However, Keylor Navas was quickly off his line.
Madrid continued to play a high defensive line and were almost caught out again just before half-time, but Salah could not provide a finish.
Szczesny was called into action again at the start of the second-half when he saved from Rodriguez and then Ronaldo.
Madrid eventually went ahead after 64 minutes when Ronaldo converted substitute Vazquez Lucas' cross from the right.
Rodriguez added a second three minutes later, the Colombian slotting through Szczesny's legs after being played into the left of the area by Ronaldo.
The Portuguese forward missed a chance to make it 3-0 when he dragged a shot wide.
Roma were denied a late consolation when Diego Perotti's strike came back off the post.