Wolfsburg stunned Real Madrid with two goals in eight first-half minutes to take control of their Champions League quarter-final tie.
The 10-time winners of the competition face an uphill task just to progress to the last four this year after losing 2-0 in Germany in the first leg.
Real goalkeeper Keylor Navas had not conceded in this competition prior to this game but he was finally beaten after 738 minutes without doing so when Ricardo Rodriguez sent him the wrong way from 12 yards out in the 18th minute.
The spot-kick was debatable as Andre Schurrle appeared to kick his own foot as he swung his leg past Casemiro, who was on the wrong side of the German.
Seven minutes later it was 2-0, Julian Draxler finding Henrique in space and from his cross Maximilian Arnold stole a march on Sergio Ramos and finished.
Zinedine Zidane's side pushed for an away goal after the interval and Cristiano Ronaldo missed with two attempts from Gareth Bale crosses, while Navas pushed away from Max Kruse late on to ensure the task facing Real in the second leg did not become even more difficult.