RB Leipzig 3 Tottenham Hotspur 0
Tottenham were unable to deliver another Champions League miracle as they were torn apart by RB Leipzig in the last-16.
Shorn of key players in attacking areas, Spurs had to overcome a 1-0 first-leg deficit, but slumped to a 3-0 defeat in east Germany and crashed out.
Marcel Sabitzer scored twice in the opening 21 minutes, with Hugo Lloris culpable for both, to put Spurs on the brink and they were unable to reproduce their amazing comeback from the same situation at Ajax in last season's semi-final.
Emil Forsberg completed the rout late on with his first touch as Spurs went with a whimper.
It leaves Jose Mourinho with no prospect of silverware in what has been an eye-opening first few months at the club.
He now has nine games left in the Premier League to try and ensure Tottenham are back in this competition next season, but even that is looking unlikely.
There are some mitigating circumstances for this defeat as any side would struggle missing the calibre of players such as Harry Kane, Son Heung-min, Moussa Sissoko and Steven Bergwijn.
But the way they were unable to repel Leipzig over the 180 minutes highlights how weak they are in defence, with goalkeeper Lloris also letting them down on the first two goals.
The Bundesliga side are no mugs and 32-year-old manager Julian Nagelsmann has enhanced his glowing reputation by delivering them to a first Champions League quarter-final.
Mourinho had been bullish about his side's chances of progressing, but knew it would take "something special".
Mourinho's hope would not have been built around the plan of going 2-0 down inside the opening 20 minutes.
Leipzig cut their defence open at will, though goalkeeper Lloris must face an inquest.
In the 10th minute, the France captain, culpable for a goal at Burnley on Saturday, failed to keep out Sabitzer's scuffed shot from 20 yards despite getting a hand to it.
Timo Werner had a goal rightly chalked out for offside, but Leipzig got their second and again Lloris must take some of the blame.
Serge Aurier does not come out with much credit either as he misjudged a header and then allowed Angelino to get a cross in too easily, but Lloris still should have saved Sabitzer's header, having got another hand to it.
Spurs had a mountain to climb, but it was tough for them without key men in attack.
The influential Giovani Lo Celso started to get into the game and had Spurs' first effort on goal as his low curling effort forced Peter Gulacsi into a stretching save.
Spurs had plenty of the ball in the second half, with the visitors happy to sit off and hit them on the counter-attack, a ploy which saw Patrik Schick and Werner blaze off target.
Dele Alli had Spurs' only chance of the second half as he shot straight at Gulacsi and Spurs were punished in the final five minutes.
Forsberg had only just come on and he was on hand to rifle home from Angelino's pass and complete Tottenham's painful misery.