La Liga has confirmed that five players have tested positive for coronavirus.
All five unnamed players across the leagues top two divisions - are asymptomatic and in the final phase of the disease but will now go into quarantine and be unable to return to group training until they have had two negative tests.
The Spanish league resumed group training this week with a view to resuming their league in June.
A LaLiga statement read: "After completing the medical tests on the minimum essential personnel referred by the clubs to start training, some cases of Covid-19 have been detected. Specifically, between the clubs of LaLiga Santander and La Liga SmartBank, five positive cases have been detected in players, all of them asymptomatic and in the final phase of the disease."
Meanwhile, Dynamo Dresden, who play in the second tier of German football, have put their entire squad and coaching staff into two-week isolation after two players tested positive for coronavirus.
The Bundesliga and Bundesliga 2 are due to restart on Saturday, May 16.
It is set to be the first European league to restart following the coronavirus shutdown.
"The fact is that we can neither train nor participate in a game in the next 14 days," said Dynamo.