Dungannon Swifts striker Daniel Hughes could miss the rest of the season through injury.
The 27-year-old picked up a shoulder problem against Ballymena United last Tuesday.
Winger Caolan McAleer (26) also sustained ankle ligament damage in the Irish Cup defeat to Cliftonville and he too faces a spell on the sidelines.
Dungannon boss Kris Lindsay said both may not return before the campaign concludes.
"It is looking like Daniel could be out for four to six weeks, and Caolan might be similar," he said.
"If we can get them back before the end of the season it will be a bonus."
Hughes has spent large periods of the campaign on the sidelines.
He missed the first month of the season, then was absent for almost three months after an ankle injury sustained in early November.
Lindsay added: "It is hugely disappointing because he has looked very good in the last couple of weeks.
"He has had a stop-start season with a few long-term injuries. It's one of those things, but Daniel is a quality player and he will come back stronger.
"Hopefully we will get him back before the end of the season and, if not, we will look forward to having him back fully fit next term."
McAleer, who has impressed since joining in the January window, is also facing four to six weeks out.
Young forward Ben Gallagher will miss the remainder of the campaign too.
Lindsay said: "I have told the boys that we will use our whole squad between now and the end of the season.
"People will get their opportunities and it is up to them to take it."
Dungannon remain 12 points above the drop zone going into the last seven games after a 4-4 draw with Warrenpoint on Saturday.