Liam Boyce scored his first hat-trick for Burton to help seal a place in the second round of the Carabao Cup while, elsewhere, Mark Sykes' first goal in English football kick-started a late Oxford comeback win.
Northern Ireland forward Boyce scored twice before the break and added a third midway through the second half as Morecambe were swept aside 4-0.
Elsewhere, Sykes helped League One Oxford spring a shock against Championship side Millwall with a 4-2 penalties victory.
The U's were 2-0 down and all but certainly heading out with three minutes remaining before Sykes and a James Henry penalty levelled matters at to send the second-round match to a shoot-out.
Oxford then triumphed with four successful penalties, while Millwall missed one and had one smartly saved by Simon Eastwood.
Iceland international Jon Dadi Bodvarsson had earlier struck a goal in each half to put the Lions seemingly in charge. The summer signing from Reading ran through when Tom Elliott flicked on Luke Steele's long ball after 29 minutes and slotted past Eastwood.
He again showed good finishing with a deft glancing header from Jason McCarthy's right-wing cross seven minutes into the second half.
But Sykes pulled one back for the U's with a low effort from the edge of the box after 87 minutes.
And - when substitute Ben Woodburn was fouled in stoppage time by McCartny - Henry tucked away the resulting penalty.
Meanwhile, Norwich were dumped out by League Two Crawley as Bez Lubala’s deflected first-half strike was enough to secure a 1-0 win for Town.
Daniel Farke’s decision to change all 11 starters for the Canaries proved costly as the Premier League new boys produced a disjointed performance and were duly punished.
Lubala’s 18th minute goal, his fifth in six outings, came against the run of play but Norwich struggled to produce a response after it flew past Ralf Fahrmann.
Patrick Roberts struck a post and Emi Buendia sent a shot on to the crossbar but Crawley had plenty of chances to add to their lead and were worthy winners.
And Norwich were not the only top-flight side to fall as Colchester beat Crystal Palace on penalties after a goalless draw at Selhurst Park, with Noah Chilvers scoring the decisive kick as Colchester scored all five from the spot.
Sheffield United were unconvincing in seeing off Blackburn 2-1 at Bramall Lane. Richard Stearman and Ollie Norwood scored first-half goals after Blackburn’s Adam Armstrong saw an early penalty saved, but Sam Gallagher’s header set up a nervy finish.
Aston Villa had no such trouble in winning 6-1 at Crewe. Ezri Konsa’s debut goal four minutes in was followed by a first-half brace from Conor Hourihane after Owen Dale’s 18th minute header was ruled out for offside for Crewe.
Further goals followed from Keinan Davis and Frederic Guilbert as Villa filled their boots, and though Ryan Wintle pulled one back with a fine solo effort, Jack Grealish had the final word.
Watford eased the pressure on Javi Gracia with their first win in nine games, comfortably seeing off Coventry 3-0.
Record signing Ismaila Sarr opened the scoring in the 37th minute with his first Watford goal before Daryl Janmaat and Adalberto Penaranda added to the score in the second half.
Brighton needed a stoppage time winner from Glenn Murray to win 2-1 at Bristol Rovers, having seen Aaron Connolly’s slightly fortunate opener cancelled out by an excellent goal from Tom Nichols.
Michael Obafemi’s 57th header saw Southampton to a 1-0 win at Fulham while West Ham overcame a strong Newport start to triumph 2-0 at Rodney Parade with goals in either half from Jack Wilshere and Pablo Fornals – each scoring their first for the club.
Stoke eased the pressure on Nathan Jones with a dramatic victory at Leeds on penalties.
Danny Batth’s header and Sam Vokes’ close-range finish put Stoke 2-0 up but Jack Butland’s miserable run of fortune continued when his clearance struck a defender and fell for Eddie Nketiah to finish before Helder Costa levelled in the 81st minute.
But as the game headed to penalties, Butland was not hiding as he took and scored Stoke’s fifth penalty before Jack Harrison struck a post.
Nottingham Forest cruised to a 3-0 win over rivals Derby as Albert Adomah opened the scoring before further goals from Joe Lolley and Joao Carvalho.
Yakou Meite scored twice at the death, one from the penalty spot, as Championship side Reading won 4-2 at League Two Plymouth, who led twice on the night.
James Henry scored from the spot in the fourth minute of stoppage time as League One’s Oxford came from 2-0 down to force penalties against Championship Millwall, and they capitalised as John Mousinho drilled the decisive spot-kick past Luke Steele.
Luton won 3-0 away to fellow Championship side Cardiff after a Junior Hoilett own goal and further strikes from Alan Sheehan and Jake Jervis.
Rochdale were 2-1 winners over Carlisle while MK Dons were 4-1 winners away to Southend in another all League One tie.
Jarrod Bowen’s goal in the fifth minute of stoppage time saw Hull force penalties against Preston as it finished 2-2, with Preston winning 5-4 in the shoot-out.
The game between Grimsby and Morecambe at Blundell Park was abandoned at half-time after a torrential storm with the score 0-0.