Manchester-born Danny Welbeck is likely to lead the line for Arsenal when they travel to face Manuel Pellegrini's City on Sunday and is hoping to take advantage of any despondency among the hosts.
Manchester City lost 1-0 to Real Madrid in their Champions League semi-final on Wednesday night to miss out on a first final appearance.
They are also three points adrift of Arsene Wenger's Gunners in the race for third place, which guarantees qualification for the Champions League group stages.
Victory for Arsenal would ensure they finish above City and former Manchester United forward Welbeck is hoping for a memorable return having missed the trip to the Etihad Stadium last season.
He said: "For them to be going into a Champions League semi-final second leg and having the opportunity to progress to the final is a major situation. Them not qualifying will put a bit of a downer on their confidence but City have a great squad, a great team and have great players in and around the whole club.
"There's a lot of players who can come in on the weekend and provide a very stern test for Arsenal.
"I've got some good memories (playing against Man City), and a couple of bad ones as well. I think it's important to focus on the next game coming and make sure that it's another good memory."
Victory for Welbeck and his team-mates could even keep them in the race for second place to again finish above fierce rivals Tottenham.
Spurs' title-race only came to an end when they drew at Chelsea last week.
It means Arsenal are now just three points adrift of a side who have never finished above them under Wenger - who has not given up on extending that run.
"It's not over," Wenger said on the race for second.
"Let's see what happens until the end of the season. Tottenham had a good season. They didn't manage to finish very strongly recently but overall they've had a good season and they have a strong team.
"But our target is still to get in front of them if possible. If Tottenham do that (finish above Arsenal), you can at least say it's a one off, because in 20 years, it will have happened once.
"At the moment it's not done. If they do it, well done. We'll fight until the end to make sure that we have a chance that we get in front of them."