Chelsea hope either Diego Costa or Loic Remy will be fit for Sunday's match at Arsenal after Didier Drogba suffered an ankle injury.
The 37-year-old Ivory Coast striker has led the Premier League leaders' attack in wins over QPR and Manchester United in recent weeks due to Costa's hamstring injury and Remy's calf problem.
Drogba, a United Nations Development Programme Goodwill Ambassador, on Monday withdrew from featuring in the Match Against Poverty in St Etienne.
He wrote on Twitter: "Disappointed not to be able to play the #MAP2015 because of an ankle injury but still supporting #EbolaResponse."
It is not the first time Drogba has had an ankle problem this season.
He has made five Premier League starts this campaign, but could be displaced in Chelsea's starting line-up at the Emirates Stadium anyway if Costa or Remy is fit.
"Our target was for Diego to play the last four matches and Arsenal is the sixth match from the end," Mourinho said last Friday.
"He starts training with rest of the squad next week."
Mourinho also reported Remy had a better than 50 per cent chance to play against United, although teenager Dominic Solanke was on the substitutes' bench, with the France striker ruled out.
Chelsea are 10 points clear of the second-placed Gunners and victory against Arsene Wenger's men will mean the Blues can wrap up the title at Leicester three days later.