Manchester City striker Edin Dzeko could miss the next three weeks with a "very serious" calf injury.
Dzeko was forced from the field just four minutes after replacing Fernandinho during the second half of City's 2-2 Barclays Premier League draw at QPR on Saturday, and he has been ruled out of Bosnia-Herzegovina's Euro 2016 qualifier against Israel on Sunday.
Reports suggest that Dzeko could also be unavailable for City's upcoming league fixtures against Swansea and Southampton, and their Champions League tie against Bayern Munich.
Bosnia-Herzegovina team doctor Reuf Karabeg confirmed that Dzeko will miss Sunday's match against Israel.
"It's a very serious injury and requires the kind of treatment whose time-frame unfortunately rules out a quick return," Dr Karabeg said on the Bosnia-Herzegovina Football Federation website.
Dzeko said: "I am extremely disappointed with the news that I will miss this match but I have faith in my team-mates and believe that they have it in them to get a result."
The Dragons are second from bottom in Group B, with two points from their first three matches.
City captain Vincent Kompany, meanwhile, will miss Belgium's friendly against Iceland on Wednesday with a calf injury, national team boss Marc Wilmots revealed on Sky Sports News.
The 28-year-old centre-back missed Saturday's draw at Loftus Road with the injury, but could recover in time to play in Belgium's Euro 2016 qualifier against Wales in Brussels on Sunday.