Pep Guardiola made a winning start as Manchester City manager after dropping England goalkeeper Joe Hart to the bench.
City beat Sunderland 2-1 at the Etihad Stadium in the late kick-off, but Guardiola was grateful for Sunderland defender Paddy McNair's own goal three minutes from time.
McNair only arrived on Wearside from Manchester United on Thursday and he was the unwitting villain as Jesus Navas' cross ricocheted off goalkeeper Vito Mannone and hit him on the head to go in.
Guardiola made an immediate impact by dropping Hart - with Willy Caballero preferred in goal - and Yaya Toure, but City took a third-minute lead when Raheem Sterling was felled in the penalty area and Sergio Aguero converted from the spot.
But City failed to build on that and created little despite dominating possession.
Sunderland equalised through Jermain Defoe 19 minutes from time, but David Moyes was unluckily denied a point in his first game as Black Cats boss.
Leicester became the first reigning Premier League champions to lose their opening game as they suffered a shock 2-1 defeat at Hull.
The newly-promoted Tigers had suffered a chaotic summer in losing manager Steve Bruce and supporters protesting at the Allam family ownership of the club.
Injuries had left caretaker boss Mike Phelan with only 13 senior players in his squad, but Hull somehow overcame the odds to stun Claudio Ranieri's champions.
England striker Jamie Vardy, so lethal last season, wasted two inviting opportunities for the Foxes before Adama Diomande's acrobatic effort on the stroke of half-time gave Hull the lead.
Leicester levelled within seconds of the re-start when Tom Huddlestone caught Demarai Gray marginally outside the area, but referee Mike Dean awarded a penalty which Riyad Mahrez coolly converted.
Hull, however, bounced back and Robert Snodgrass' clinical finish after 57 minutes secured a famous victory.
The Ronald Koeman era at Everton began with a 1-1 draw against Tottenham.
Everton's first goal under former Southampton boss came within five minutes when Ross Barkley's speculative free-kick evaded everyone in the penalty area to find its way into the Spurs net.
But Spurs - who lost goalkeeper Hugo Lloris to injury in the first half - secured a point at Goodison Park when Erik Lamela headed home Kyle Walker's 59th-minute cross from close range.
Stoke also fought back to draw 1-1 at Premier League new boys Middlesbrough.
Former Manchester City forward Alvaro Negredo, making his debut on loan from Valencia, gave Boro an 11th-minute lead when he latched on to Gaston Raimirez's header.
Ramirez struck a post before half-time and Boro were made to pay when Xherdan Shariqi's splendid 67th-minute free-kick beat Victor Valdes.
Ten-man Watford held on to draw 1-1 at Southampton following substitute Ben Watson's 75th-minute dismissal.
New Watford boss Walter Mazzarri was celebrating when Etienne Capoue's first Hornets' goal gave the visitors a ninth-minute lead.
But Southampton levelled when the debut-making Nathan Redmond volleyed home after Heurelho Gomes failed to get distance on his punch from a corner.
Watson, who had been on the pitch for only 12 minutes, was sent off after being shown a straight red card for bringing down Shane Long but late Saints pressure failed to find winner.
Leroy Fer's first Swansea goal gave the Welsh club a 1-0 win at newly-promoted Burnley.
Fer made his loan switch from QPR permanent in the summer and he celebrated when he pounced on a rebound eight minutes from time.
Burnley were denied a late equaliser when Lukasz Fabianski saved brilliantly from Dean Marney.
West Brom boss Tony Pulis enjoyed a 1-0 win at former club Crystal Palace.
It was a game of few chances, but Salomon Rondon's glancing header from James McClean's 74th-minute cross settled matters.