Brighton struck a major blow in the title race as Steven Alzate's first Premier League goal inflicted a shock 1-0 defeat on Liverpool at Anfield.
The Seagulls ace fired home in the second half to condemn Jurgen Klopp's misfiring Reds to their second straight home defeat, which leaves them seven points off the top.
That position is held by Manchester City, who restored their three-point lead with a straightforward 2-0 win over Burnley at Turf Moor.
Pep Guardiola's men, who were pegged back at the top by city rivals United on Tuesday, quickly reclaimed their place at the summit as goals from Gabriel Jesus and Raheem Sterling led the visitors to their 13th straight win.
Leicester moved above Liverpool to third with a 2-0 win over Fulham. West Ham are in fifth after a 3-1 win at Aston Villa.