Liverpool's four-match winning run was halted by a lively Wigan in a 1-1 draw at the DW Stadium as Roy Hodgson's side faded badly after taking an early lead.
Despite being given an early advantage by Fernando Torres' third goal in four days, the visitors lost their grip on the game midway through the first half and never regained it.
Wigan equalised through Hugo Rodallega and finished the better side as the Merseysiders appeared to feel the exertions of beating Chelsea on Sunday.
The Reds began strongly with Lucas Leiva unleashing a 25-yard strike which Ali Al Habsi just managed to tip over.
The next time the visitors attacked the goalkeeper was given no chance by a clinical Torres. All Liverpool's league goals, apart from their opening match against Arsenal, have either been scored or provided by Steven Gerrard and Torres.
Gerrard was given far too much time to carry the ball through midfield. His perfectly-weighted 30-yard pass allowed Torres to outpace Gary Caldwell and fire across Al Habsi into the far corner of the goal.
Torres was looking at his dangerous best and when Antolin Alcaraz stumbled he was clean through only for referee Peter Walton to pull play back for a non-existent foul.
Charles N'Zogbia looked Wigan's best outlet and he thought he had equalised when he seized on Lucas' weak pass and played a one-two with Rodallega to tap home but his team-mate had already been flagged offside.
Rodallega did level when Jose Reina could only palm Ronnie Stam's low cross into his path and he gratefully fired home left-footed.
Gerrard's shot 10 minutes from time crashed down off the crossbar but not over the line with Al Habsi beaten as the game became end-to-end. But it was Liverpool who were grateful for the final whistle as Mohamed Diame and N'Zogbia both forced low saves out of Reina.