Derry qualified for the semi-finals of the Bank of Ireland Dr McKenna Cup, in which they will meet Cavan, after defeating Queen's at Celtic Park.
Derry, as the best runners-up in the groups, now join Tyrone, Fermanagh and Cavan in this weekend's semi-finals.
True to his word, Derry boss Damian Barton made as many as 12 changes to the team that started in the defeat to Tyrone and gave competitive debuts to Peter Quinn, Shane Mulgrew, Gavin McWilliams and goalkeeper Ciaron O'Boyle.
Defeats at the hands of Tyrone and Antrim left the students nothing to play for other than sharpening their match fitness for the upcoming Sigerson Cup campaign.
Queen's led 1-02 to 0-04 after Gerard McGovern scrambled home a goal in the 17th minute.
The home team dominated the remainder of the half with Enda Lynn prominent as Derry ran in 0-10 to 1-05 ahead at the break with debutant Conor Kearns scoring three points.
Queen's trailed by a point when Martin Clarke converted a 47th minute free.
James Kielt, Ryan Bell and man of the match Kearns - hitting his fifth from play - were then among the scores as Derry prevailed by three points.
Despite losing Anthony Doherty to a second card, Dermot McAleese scored a second goal for Queen's late on.
Scorers: Derry: Conor Kearns 0-5, Ryan Bell 0-3, Mark Lynch 0-2 (0-1f), Chrissy McKaigue 0-1, Neil Forester 0-1, Shane Mulgrew 0-1, Shane McGahon 0-1, James Kielt 0-1, Niall Loughlin 0-1, Shane Heavron 0-1
Queen's: Dermot McAlees 1-1, Gerard McGovern 1-1, Martin Clarke 0-2f, Ciaran Harney 0-2 (0-1f), Brendan Rogers 0-1, Shea Heffron 0-1.