Mickey Harte's Tyrone will have to cope without influential forward Lee Brennan for the next eight weeks as they aim to reach the Super 8s through the back door.
Brennan aggravated a pre-existing hamstring injury in the Red Hands' 1-18 1-16 defeat to Monaghan on Sunday and will have to sit out nearly two months with the ailment.
The Trillick club man was a major doubt leading up to the game, but Harte elected to start the 21-year old only to see him come off midway through the second half.
It's not quite as bad for Mark Bradley, however he too will have to miss a significant period of five weeks after he suffered ankle ligament damage in the early stages of the quarter-final loss at Healy Park.
Having come under scathing criticism for starting several players with knocks - including Colm Cavanagh and Tiernan McCann, who both also had to be substituted - this was the last thing Harte needed to hear this week.
With Peter Harte also suspended for their first round qualifier, the draw for which is on Monday, the Red Hands boss will have to cope with a severely depleted panel for a game that could be against 2017 runners-up Mayo if the draw is unkind to them.