In-form Queen's University are on the cusp of the play-offs and meet Highfield, who have already won Division 2A, at the Dub.
The fourth-placed students, who have won their last five games and all with try bonuses, need just two points from their last two fixtures to ensure their place in the knockout stages.
However, coach Derek Suffern's squad will want the win over Highfield, who have nothing to play for, to potentially finish higher in the table.
"It's the first time in a long time that we have put ourselves in this position," said the students' team manager Chris Moore.
"Six bonus point wins out of seven games since Christmas have meant we are getting the rewards but it is not done yet."
In 2B, Rainey Old Boys can pretty much wrap up third spot if they win at Wanderers and though Charlie Clarke is back they are without Tim Barker and Paddy McGowan for the trip.
Belfast Harlequins, in ninth, need a win at bottom side Sunday's Well to potentially put the hosts down while eighth-placed Dungannon need to beat Sligo.
Omagh must win at Malahide to keep their hopes alive of making the 2C play-offs while City of Derry, in seventh, and Bangor, down in eighth, are in dire need of results.
Derry host Bruff while Bangor are at basement side Thomond.
2A: QUB v Highfield. 2B: Wanderers v Rainey, Dungannon v Sligo, Well v Quins. 2C: Thomond v Bangor, Derry v Bruff, Malahide v Omagh