Aidan O'Brien's colt Recital has been ruled out of Sunday's Dubai Duty Free Irish Derby and is not among the nine still left in the race.
The three-year-old won the Derrinstown Stud Derby Trial earlier in the year, Ireland's premier prep race for the Epsom Derby, but he failed to act on the unique Downs, with Pat Smullen guiding him into sixth place.
Recital had been as low as 4-1 for the Curragh contest, but O'Brien's wife Annemarie tweeted: "We weren't 100 per cent happy with Recital this morning so he will not run in the Derby on Sunday. Roderic O'Connor will be left in the race and is a possible to run instead."
The Ballydoyle handler still looks certain to be well represented as he chases a remarkable ninth success in the race.
Roderic O'`Connor is one of four O'Brien entries, along with Epsom runner-up Treasure Beach, the fourth home Memphis Tennessee and the disappointing Seville.
Sir Michael Stoute's Carlton House, owned by the Queen, was third when sent off favourite for the Derby and remains in the mix, as does Ed Dunlop's Epsom fifth Native Khan.
Best Hello, Dunboyne Express and Notable Graduate complete the nine entries.
Paddy Power make Carlton House the 5-4 favourite and the bookmaker expects there to be plenty of takers at those odds.
Power said: "The likelihood that Carlton House is going to take part in the Irish Derby is creating a buzz around the race unlike I've ever known before.
"Considering he was sent off 5-2 favourite for the English equivalent, I could see punters really getting stuck in and possibly even going off an odds-on jolly."