Irish challenger Sir Isaac Newton weakened into seventh as Jameka claimed a hugely impressive victory in the Group 1 BMW Caulfield Cup.
Sir Isaac Newton was bidding to give Aidan O'Brien his first ever Caulfield Cup, and the Galileo colt rounded the home turn as one of the leaders .
However, Ciaron Maher's Jameka was looming up ominously on the outside and shot clear inside the final furlong to win decisively under a jubilant Nicholas Hall.
British raider Scottish performed admirably to finish a clear second, with Exospheric, formally known as Exosphere when running for Sir Michael Stoute earlier this year, a fast-finishing third.
Sir Isaac Newton faded out of contention late in the day, but was not disgraced.
Hall said: "I've got to really thank Ciaron Maher and the stable. He's taken on a lot of horses and done an exceptional job.
"The way he's prepped this filly run by run has been to win this race and he's won it."
Maher said: "When you're favourite I suppose it puts a bit of extra pressure on, but it's just a great job by the team.
"Nick had her in a perfect spot and looked pretty confident all the way, so I was calm.
"There's nothing better than winning a Caulfield Cup. I don't know if it's really sunk in yet. This is basically our back yard, so to pull it off is a great effort.
"She's just been an outstanding horse. She won a two-year-old race taking on the boys, we took on the boys in the Derby in the autumn - she's always shown that's not a problem for her.
"During this prep she's just gone to another level."
Jameka now looks set to line up as a major contender for the Melbourne Cup on the first Tuesday in November.
"I think she's improved every start into this race. It's hard to say she'll improve again, but I'm happy to try the two miles now," the trainer added.