Saturday, January 9
Exeter (2) v Gloucester (6)
Lock Ollie Atkins, openside Julian Salvi and wing James Short are drafted into Exeter's starting XV. Jack Nowell moves from wing to outside centre.
Gloucester have made two changes following their win against London Irish with scrum-half Greig Laidlaw and number eight Ben Morgan returning to the starting XV.
Last season: Exeter 25 Gloucester 26, Gloucester 22 Exeter 25
Top Try Scorers: James Short,Thomas Waldrom (Exeter) 4 Sione Kalamafoni (Gloucester) 3
Top Point Scorers: Gareth Steenson (Exeter) 117 Greig Laidlaw (Gloucester) 83
Harlequins (3) v Saracens (1)
England prospect Jack Clifford starts at number eight with Nick Easter dropping to the bench as part of Harlequins' rotation policy. Prop Adam Jones and wing Marland Yarde are also back.
Saracens have named Neil De Kock and Owen Farrell at half-back, while Duncan Taylor replaces leg-injury victim Brad Barritt at inside centre. Jamie George captains the team at hooker.
Last season: Saracens 42 Harlequins 14, Harlequins 0 Saracens 39
Top Try Scorers:Tim Visser (Harlequins) 5 Mike Ellery (Saracens) 3
Top Point Scorers: Nick Evans (Harlequins) 127 Owen Farrell (Saracens) 104
Leicester (4) v Northampton (5)
England front rows Dan Dole and Tom Youngs return to bolster Leicester's scrum and Owen Williams supplants Freddie Burns at fly-half. Brendon O'Connor starts at openside.
Dylan Hartley continues on Northampton's bench with Mark Haywood preferred at hooker. Tom Wood has recovered from a shoulder problem and is among the replacements.
Last season: Leicester 22 Northampton 14, Northampton 23 Leicester 19
Top Try Scorers:Telusa Veainu(Leicester) 4 Luther Burrell, Christian Day, Ben Foden (Northampton) 2
Top Point Scorers: Tommy Bell (Leicester) 64 Stephen Myler (Northampton) 88
Sunday, January 10
London Irish (12) v Newcastle (11)
Blindside flanker Jebb Sinclair and full-back Topsy Ojo are the two changes made by London Irish.
Newcastle have made two changes following their victory over Bath with hooker Scott Lawson and prop Paddy Ryan winning starts.
Last season: London Irish 22 Newcastle 21, Newcastle 18 London Irish 20
Top Try Scorers: Johnny Williams (London Irish) 2 Rob Vickers (Newcastle) 2
Top Point Scorers: Chris Noakes (London Irish) 46 Tom Catterick (Newcastle) 34
Wasps (9) v Worcester (10)
Wasps have made four changes after the defeat at Sale with wing Josh Bassett, wing Sailosi Tagicakibau, hooker Edd Shervington and lock Kearnan Myall starting.
Injury has forced Worcester into making several changes with scrum-half Charlie Mulchrone, fly-half Ryan Mills, centre Andy Symons, wing Tom Biggs and flanker Sam Batty starting.
Last season: No Corresponding fixture
Top Try Scorers: Frank Halai (Wasps) 4 Cooper Vuna (Worcester) 3
Top Point Scorers: Jimmy Gopperth (Wasps) 83 Tom Heathcote (Worcester) 47