Worcester suffered a miserable night in south Wales as their European Challenge Cup quarter-final hopes were dented by Newport Gwent Dragons at Rodney Parade.
The Warriors were beaten 22-7 and also had back-row forward Sam Betty sent off midway through the first half.
Reduced to 14 men for more than an hour - Betty received a red card from referee David Wilkinson following a flare-up involving both sets of forwards - Worcester were undone by second half tries from Dragons substitute Tyler Morgan and prop Sam Hobbs.
Connor Braid converted his own try to give Worcester an early lead, but that was soon cancelled out by a Tavis Knoyle touchdown that Angus O'Brien converted, with O'Brien adding another conversion and penalty.
It meant the Warriors dropped to the bottom of Pool Three, while Brive remained top of the group after scoring six tries to see off Russian opponents Enisei-STM 38-18 in France.
A comfortable home win was never in doubt after Brive scored three first-half tries, while their opponents did not help their cause by having three players sin-binned.
Former England wing Tom Varndell claimed a hat-trick of tries as Aviva Premiership strugglers Bristol recorded back-to back victories over French club Pau.
Bristol, without a league win this season, followed up last weekend's victory at Ashton Gate to claim a 28-18 Pool Four verdict in south-west France.
Varndell claimed his opener just before the break, and then added two more during nine second-half minutes as Bristol claimed a bonus triumph to stay in touch with group pace-setters Bath and Cardiff Blues.
Jack Wallace also touched down for the west country club, while Jason Woodward and Adrian Jarvis each kicked two conversions.