The clash at Judges Road between leaders City of Derry and second-placed Highfield ensures that Division 2B gets top billing for this weekend's games.
Derry's only defeat from their previous 10 games has been to the Cork side and came after a rather lengthy 12 minutes of second half injury-time which saw Highfield snatch the result.
Derry coach Terry McMaster said: "We're still sore about the loss down there. We are relishing the chance to put that right as we have been aggrieved about it ever since. Judges Road has been a bit of a fortress this season."
Selection-wise, Richard McCarter is back at out-half after being rested last week and Richard Baird is back in the squad.
With 11 points already between the top two sides, Derry can make a statement should they stretch their lead further.
In 2A, second-placed Malone tripped up badly at Queen's last week and a frustrated Jarrett Truscott is intent on putting things right this time around, though the Gibson Park side are on their travels at Nenagh.
"It gives Banbridge breathing space and puts pressure on us," said Truscott. "It is a wake-up call. We're going to Nenagh and need to win."
Malone have Richard Millar in the second row for the injured James McAlister while Ben McDonnell is at No.8 as Ross Todd is unavailable.
Elsewhere in 2A, Banbridge host UCC and are out to stretch their lead at the top while sixth-placed Queen's University are at home to Cashel who are in fifth.
The other games in 2B see Rainey host Greystones while Armagh and Dungannon are on the road at Bective and Barnhall respectively.