Rainey Old Boys have a fifth straight win in their sights when they host Old Crescent at Hatrick Park.
The Magherafelt club are second in the 2A table and just three behind leaders MU Barnhall, so confidence is fairly high that Rainey can keep their own winning run going.
"If we play the way we are playing then I think we can comfortably match them up front," said director of rugby Brian Smyth of what will likely be key to the game.
Coach John Andrews has made minimal alteration to his side with Andrew Donaghy coming in on the wing and Josh McAuley at flanker.
Queen's University will be aiming to prevent a third consecutive defeat when the now fourth-placed students play leaders Barnhall, who have yet to lose, at The Dub.
Also in 2A, Ballymena, who are sixth, entertain third-placed Cashel.
In 2B, Dungannon will be seeking to follow up last weekend's bonus point victory over Ballina - the eighth-placed Tyrone side's first win - when they travel to Galway to take on Corinthians.
Belfast Harlequins, who are in ninth, are also on the road and they take on mid-table Malahide.
In 2C, fourth-placed Omagh are at home to Bruff, who are a place above them, while City of Derry, in fifth, are at Tullamore.
Bangor, down in ninth, are at second-placed Skerries.
2A: Ballymena v Cashel, Queen's University v MU Barnhall, Rainey Old Boys v Old Crescent
2B: Galway Corinthians v Dungannon, Malahide v Belfast Harlequins
2C: Omagh Accies v Bruff, Skerries v Bangor, Tullamore v City of Derry