Northampton have rested their England contingent for Thursday's Amlin Challenge Cup quarter-final against Sale.
Centre Luther Burrell, lock Courtney Lawes and flanker Tom Wood have been omitted from the 23, while hooker Dylan Hartley has been ruled out with a shoulder injury. Wales wing George North has also been left out.
All five players started Northampton's two matches immediately after the RBS 6 Nations, including Saturday's 22-16 Aviva Premiership defeat by Leicester.
Lee Dickson starts ahead of Kahn Fotuali'i as one of seven changes and despite the overhaul of the team, the England scrum-half insists winning the Challenge Cup remains a target.
"It would mean loads to us to win a trophy. This year we got to the LV= Cup final but unfortunately that went in Exeter's favour," Dickson said.
"We want to win trophies as players - that's why we are at Northampton - and nothing has changed heading into this week's game.
"Now we go up to Sale which we know will be tough. They're very, very good in defence and pride themselves on that.
"They're a solid team and the way they've turned things around from last year. You have to respect that."
Sale have also made wholesale changes as they concentrate their efforts on securing a place in the Aviva Premiership play-offs, among them a new half-back pairing of Nick Macleod and Will Cliff.
Danny Cipriani and Dwayne Peel have been left out of the 23 after starting Friday's 12-11 victory over Bath.